Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana
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منابع مشابه
Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana
Classical pharmacology has been the basis for the discovery of new chemical entities with therapeutic effects for decades. In natural product research, compounds are generally tested in vivo only after full in vitro characterization. However drug screening using this methodology is expensive, time-consuming and very often inefficient. Reverse pharmacology, also called bedside-to-bench, is a res...
متن کاملNeuropharmacological study of Argemone mexicana Linn
In the present study methanolic and ethyl acetate extracts of Argemone mexicana whole plant (Papaveraceae) were tested orally in swiss albino mice at doses of 100 mg/kg, 200 mg/kg and 400 mg/kg b.w. for CNS related activities. Papaveraceae family is known to have CNS depressant activity, so A. mexicana was evaluated for CNS activities. Significant central and peripheral nociceptive activity was...
متن کاملn-alkane profile of Argemone mexicana leaves.
An n-hexane extract of fresh, mature leaves of Argemone mexicana (Papaveraceae), containing thin-layer epicuticular waxes, has been analysed for the first time by TLC, IR and GLC using standard hydrocarbons. Seventeen long-chain alkanes (n-C18 to n-C34) were identified and quantified. Nonacosane (n-C29) was established as the n-alkane with the highest amount, whilst octadecane (n-C19) was the l...
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15 صفحه اولArgemone mexicana: chemical and pharmacological aspects#
The Papaveraceae, informally known as the poppy family, are an ethnopharmacologically important family of 44 genera and approximately 760 species of flowering plants. The present work offers a review addressing the detailed chemistry and pharmacology of Argemone mexicana L. regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different pa...
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ژورنال
عنوان ژورنال: International Journal for Parasitology: Drugs and Drug Resistance
سال: 2014
ISSN: 2211-3207
DOI: 10.1016/j.ijpddr.2014.07.001